Spatial Biology
Biology in its native context — mapping gene and protein expression across intact tissue without losing location.
What this area is.
Where a cell sits is part of what it is. Spatial biology preserves tissue coordinates while measuring molecular state, revealing architecture, niches and cell–cell interactions invisible to dissociated assays.
We process spatial transcriptomics (Visium, Xenium-style) data — registration, segmentation, deconvolution and neighbourhood analysis — and connect it back to single-cell references.
Tools & technologies
What we do.
Core methods we apply in spatial biology.
Spatial transcriptomics
Visium- and imaging-based spatial expression analysis.
Registration & segmentation
Aligning images and delineating cells/regions.
Deconvolution
Resolving cell-type composition per spot.
Niche analysis
Defining spatial neighbourhoods and microenvironments.
Cell–cell interaction
Inferring signalling between neighbouring cells.
Single-cell mapping
Linking spatial spots to single-cell references.
From data to insight.
How a spatial biology project flows end to end.
Tissue section
stained & captured
Register
image alignment
Quantify
per-spot expression
Deconvolve
cell-type fractions
Niches
neighbourhoods
Interpret
architecture & signalling
Publication-grade figures.
Interactive, live-rendered visualisations used in spatial biology.
Where we go deep.
Tumour microenvironment
Spatial structure of tumour, stroma and immune niches.
Tissue architecture
Mapping functional zones within an organ.
Spatial niches
Recurrent neighbourhoods that define microenvironments.
Questions we answer.
A few of the things people ask about spatial biology — and our short answers. Ask CGB-AI for more.
Why does location matter?
Function depends on neighbours — immune exclusion, niches and signalling are spatial phenomena that dissociation destroys.
How is it linked to single-cell?
Single-cell references deconvolve spatial spots, combining fine cell-type resolution with tissue context.
Publications in Spatial Biology.
Drawn from our full record of 173 papers, filtered to this area.
Start a spatial biology project.
Tell us the biological question and the data you have — we will map out an approach.